Iranian Foreign Minister Mohammad Javad Zarif said Iran was not seeking nuclear weapons, saying Iranian Supreme Leader Ali Khamenei had banned it in a fatwa.
The minister added in a tweet on Twitter that US policies are harming the Iranian people and causing regional tension.
"Khamenei has said for a long time that we are not seeking to acquire nuclear weapons - by issuing a fatwa that forbids it ... Economic terrorism damages the Iranian people and causes tension in the region," Zarif said.
Khamenei has the highest authority in Iran, and has the final say in all affairs of the state, but is the father of the controversial nuclear program, which is the most hard-line.
US President Donald Trump withdrew from the nuclear deal with Iran last year and re-imposed sanctions on Tehran, saying the deal did not address its missile program and its "malicious influence" in the region.
Two weeks ago, Iran notified other parties to the nuclear deal - China, France, Germany, Russia and the United Kingdom - that it would give up some of its obligations under the deal, a year after the United States withdrew its unilateral agreement.
US intelligence agencies and the International Atomic Energy Agency (IAEA) say Iran has completed a secret program to develop missile-based nuclear warheads in 2003.