New drug to wipe out superbugs
It would be almost impossible for bacteria to develop resistance to the new treatment
Oliver Moody Science Correspondent
Last updated at 12:01AM, January 23 2016
British scientists have developed an antibiotic from human breast milk that can wipe out drug-resistant bacteria.
The breakthrough opens a new front in the fight against superbugs, a threat that David Cameron has warned could plunge modern medicine “back into the Dark Ages”.
A panel set up by the prime minister to tackle antibiotic-resistant bugs forecast that they would cost the world ten million lives and £700 billion a year by 2050 if the problem went unchecked.
At present the infections kill about 700,000 people each year, including at least 10,000 in Britain. Unlike most conventional antibiotics, the new drug attacks the basic biology of bacteria in a way that makes it almost impossible for them to evolve defences.
It emerged last night that ministers have not planned for a world without antibiotics. Dame Sally Davies, the chief medical officer, told The Times that Whitehall was not preparing because officials hoped powerful new antibiotics would be discovered in time.
Asked whether the government was readying plans for the disaster scenario, she said: “Not at this time, because we’re planning to sort this. But if others do not work with us, it’s not something we can sort on our own. This is a global problem. I am optimistic about this. The science is crackable. It’s doable.”
The new superbug-killing antibiotic is the type of breakthrough on which Dame Sally is relying. Developed at the National Physical Laboratory in southwest London, it can tear bacteria apart within a fraction of a second. It could also be used to treat genetic diseases such as sickle-cell anaemia by rewriting a cell’s DNA, its inventors said.
Dame Sally said that there was already a “serious prospect” of bringing new classes of antibiotic into hospitals. “We need on average ten new antibiotics every decade,” she said. “So I don’t just want some for my old age: I want them for my children’s old age, and their children’s old age. And we did disinvest as a world in this sort of research, so we need to make an investment and sustain it.”
Colin Garner, honorary professor of pharmacology at the University of York and head of the charity Antibiotic Research UK, said that the situation was too urgent to wait for international consensus. The pipeline of new drugs had dried up and the problem was on the brink of becoming “intractable”.
He said: “My heart sinks when I hear the term ‘global initiative’. How long has it taken the world to come to a sort of consensus about climate change? The problem of antibiotic resistance will be at least as intractable because each nation takes a different view of what is required.”
Adam Roberts, senior lecturer in microbial diseases at University College London, said that he was “pleasantly surprised” by Dame Sally’s optimism. “Everything’s getting into place in order to try and solve this, at least at a societal level,” he said.
The compound developed by the NPL scientists was isolated from the active ingredient in breast milk, which has long been known to have innate but weak anti- microbial properties.
Scientists rigged up part of the protein into an artificial virus that rapidly bursts bacteria while leaving human cells alone. The drug acts as a microscopic “projectile”, killing infectious bugs such as E. coli and Staphylococcus aureus at a rate comparable to established antibiotics.
Max Ryadnov, the NPL’s lead biotechnologist, said he was in talks wit drugs companies about refining his antibiotic. One of the challenges is to make sure that enough of the virus gets to the infected area without being broken h dowsn ing the threat from drug-resistant strains of bacteria such as E. coli.
Rein Ulijn, director of Central University of New York’s nanoscience initiative, said:n the bloodstream. When it meets human cells, the chemical bullet does something different. Intead of attacking them, it could be used to ferry in new instrterms of creative thinking, this is a good step forward.”
The findings appear in the Royal Society of Chemistry journal Chemical Science. uctions to rewire faulty cells in a technique known as gene therapy. It may be at least a decade before it is clear whether the drug works in the clinic, underlying the threat from drug-resistant strains of bacteria such as E. coli.
Rein Ulijn, director of Central University of New York’s nanoscience initiative, said: “In terms of creative thinking, this is a good step forward.”
Rein Ulijn, director of Central University of New York’s nanoscience initiative, said: “In terms of creative thinking, this is a good step forward.”
The findings appear in the Royal Society of Chemistry journal Chemical Science.
http://www.thetimes.co.uk/tto/science/article4672700.ece?CMP=OTH-applenews-sharing&shareToken=6cd6b58c979a648bf58aa63125b4ba3e
It would be almost impossible for bacteria to develop resistance to the new treatment
Oliver Moody Science Correspondent
Last updated at 12:01AM, January 23 2016
British scientists have developed an antibiotic from human breast milk that can wipe out drug-resistant bacteria.
The breakthrough opens a new front in the fight against superbugs, a threat that David Cameron has warned could plunge modern medicine “back into the Dark Ages”.
A panel set up by the prime minister to tackle antibiotic-resistant bugs forecast that they would cost the world ten million lives and £700 billion a year by 2050 if the problem went unchecked.
At present the infections kill about 700,000 people each year, including at least 10,000 in Britain. Unlike most conventional antibiotics, the new drug attacks the basic biology of bacteria in a way that makes it almost impossible for them to evolve defences.
It emerged last night that ministers have not planned for a world without antibiotics. Dame Sally Davies, the chief medical officer, told The Times that Whitehall was not preparing because officials hoped powerful new antibiotics would be discovered in time.
Asked whether the government was readying plans for the disaster scenario, she said: “Not at this time, because we’re planning to sort this. But if others do not work with us, it’s not something we can sort on our own. This is a global problem. I am optimistic about this. The science is crackable. It’s doable.”
The new superbug-killing antibiotic is the type of breakthrough on which Dame Sally is relying. Developed at the National Physical Laboratory in southwest London, it can tear bacteria apart within a fraction of a second. It could also be used to treat genetic diseases such as sickle-cell anaemia by rewriting a cell’s DNA, its inventors said.
Dame Sally said that there was already a “serious prospect” of bringing new classes of antibiotic into hospitals. “We need on average ten new antibiotics every decade,” she said. “So I don’t just want some for my old age: I want them for my children’s old age, and their children’s old age. And we did disinvest as a world in this sort of research, so we need to make an investment and sustain it.”
Colin Garner, honorary professor of pharmacology at the University of York and head of the charity Antibiotic Research UK, said that the situation was too urgent to wait for international consensus. The pipeline of new drugs had dried up and the problem was on the brink of becoming “intractable”.
He said: “My heart sinks when I hear the term ‘global initiative’. How long has it taken the world to come to a sort of consensus about climate change? The problem of antibiotic resistance will be at least as intractable because each nation takes a different view of what is required.”
Adam Roberts, senior lecturer in microbial diseases at University College London, said that he was “pleasantly surprised” by Dame Sally’s optimism. “Everything’s getting into place in order to try and solve this, at least at a societal level,” he said.
The compound developed by the NPL scientists was isolated from the active ingredient in breast milk, which has long been known to have innate but weak anti- microbial properties.
Scientists rigged up part of the protein into an artificial virus that rapidly bursts bacteria while leaving human cells alone. The drug acts as a microscopic “projectile”, killing infectious bugs such as E. coli and Staphylococcus aureus at a rate comparable to established antibiotics.
Max Ryadnov, the NPL’s lead biotechnologist, said he was in talks wit drugs companies about refining his antibiotic. One of the challenges is to make sure that enough of the virus gets to the infected area without being broken h dowsn ing the threat from drug-resistant strains of bacteria such as E. coli.
Rein Ulijn, director of Central University of New York’s nanoscience initiative, said:n the bloodstream. When it meets human cells, the chemical bullet does something different. Intead of attacking them, it could be used to ferry in new instrterms of creative thinking, this is a good step forward.”
The findings appear in the Royal Society of Chemistry journal Chemical Science. uctions to rewire faulty cells in a technique known as gene therapy. It may be at least a decade before it is clear whether the drug works in the clinic, underlying the threat from drug-resistant strains of bacteria such as E. coli.
Rein Ulijn, director of Central University of New York’s nanoscience initiative, said: “In terms of creative thinking, this is a good step forward.”
Rein Ulijn, director of Central University of New York’s nanoscience initiative, said: “In terms of creative thinking, this is a good step forward.”
The findings appear in the Royal Society of Chemistry journal Chemical Science.
http://www.thetimes.co.uk/tto/science/article4672700.ece?CMP=OTH-applenews-sharing&shareToken=6cd6b58c979a648bf58aa63125b4ba3e
» Militia Man & Crew Iraq- 3rd World to 1st World Country Leader with Militia Man & Angel1
» The Central Bank of Iraq is looking forward to building a partnership with the German "GIZ" and anno
» Al-Asa'ib is "angry" about border demarcation: Kuwait was an Iraqi judiciary and today it is expandi
» Central sales are declining.. and the dollar is heading up in exchanges
» The Central Bank warns Iraqis of cases of fraud
» AL-ALAQ ANNOUNCES A NATIONAL STRATEGY FOR LENDING THAT WILL COME INTO FORCE EARLY NEXT YEAR
» The outlets and the insurance company are looking into three files
» Iraqi ports announce an increase in their annual revenues to 800 billion dinars
» An economist told NINA: International understandings are the only solution to reduce the gap between
» The Economist: Not approving the budget these days will lose its economic content
» Al-Sudani directs the follow-up of local projects, the Reconstruction Fund, and projects funded by i
» Accelerate the passage of the budget on the table of Khazali and Al-Halbousi
» Iran reopens its embassy in Saudi Arabia tomorrow
» Deputy: We will not be silent about disrupting the budget, and we will resort to collecting signatur
» The Central Bank announces a national strategy for lending
» The Central Statistical Organization issues its annual report on estimates of the production of seco
» A deputy announces the arrival of the draft budget for the coalition of state forces to discuss the
» Advisor to the Prime Minister explains the importance of re-examining operating expenses and warns a
» The Central Bank: directed to build a national lending strategy that will come into effect in early
» Collect parliamentary signatures to hold a session to vote on the budget
» Parliamentary Finance: Political agreements regarding the budget "have not been decided yet"
» Parliamentary Finance: The legislative term will not be suspended without passing the budget
» The Democrat announces a preliminary agreement to pass the budget
» A compromise between the political forces to pass the budget this week
» Al-Hakim To The Kuwaiti Ambassador: The Need To Heal The Arab Rift And Support Efforts To Calm The S
» The Chairman Of The Finance Committee Sends An Invitation To The Presidency Of Parliament Regarding
» Parliamentary Finance: The budget will not be approved this week, and the parties are required to co
» Deputy for Al-Barti: Approval of the budget is associated with the political agreement to return the
» Al-Sudani chairs a meeting of the Supreme Committee for the Reconstruction of Nineveh Governorate
» Fuad Hussein announces the formation of a committee to solve the problem of Pakistan's debts to Iraq
» A legal expert explains the extent of the powers of the Finance Committee and its procedures regardi
» The Victory Coalition shows the possibility of presenting the compulsory conscription law to parliam
» Al-Barti “reaps what he wants from the framework.” Sunni leaders want to overthrow Al-Halbousi at th
» Al-Agaili: 12% of the budget goes to Kurdistan and 2% to the southern governorates
» Al-Aqabi shows the obstacles to applying the ATM financial system
» The Investment Authority: The path of development is in the process of being studied and designs dev
» In detail... Riyadh signs a contract with Baghdad to establish the "largest mall" in Iraq
» Minister of Finance: The "TSA" system will contribute to improving the quality of banks' financial s
» Member of Parliamentary Finance: The budget will not pass through a political settlement, and its ap
» Central Bank: We have provided more than 12 billion dollars to support projects
» The President of the Republic is discussing with the National Security Adviser the file of security
» Parliamentary legislative season {open} until approval of the budget
» The Ministry of Industry offers partnership with the private sector
» Tightening supervision of generator contractors
» {Human trafficking} threatens Iraq and extends to neighboring countries
» Strategic projects flock to the government's agenda
» Parliamentary legislative season {open} pending approval of the budget
» Oriented towards reforming the tax system and maximizing revenues
» Trade: The Prime Minister took “important decisions” to support the food basket
» High real estate prices push citizens to buy in neighboring countries
» Parliamentary Finance talks about developments in the voting session on the budget and the possibili
» Baghdad sends 400 billion new dinars to Kurdistan
» Taif Sami discusses reforming the tax system and maximizing non-oil revenues
» A noticeable rise in the exchange rates of the dollar, while the Sudanese are fighting a battle to l
» A slight decrease in dollar prices in Baghdad's exchange offices
» The rise in oil due to the recent “OPEC +” decisions, and Brent near $ 77 a barrel
» Parliamentary Finance: It is expected that the vote on the budget will be decided during the current
» Agriculture announces its steps to support farmers and talks about the "farmer's card"
» The exchange rates of the dollar in the Iraqi stock exchanges
» Parliamentary law suggests extending the legislative term in order to approve the budget: we only ha
» Oil Minister: Iraq decided to extend the voluntary cut of 211,000 barrels per day until the end of 2
» "Baghdad Avenue" .. Saudi Arabia announces the conclusion of a contract with Iraq to establish a hug
» The Iraqi Central Bank: A number of ministries have started entering the electronic payment project
» Militia Man & Crew BUDGET VOTE - TIMING - CONVERGENCES if you are not ready get ready!!
» KTFA Members "News and Views" Saturday PM 6-3-2023
» Judy, MilitiaMan and More Sunday Morning 6-4-2023
» In the document.. Al-Rafidain launches loans of 150 million dinars for restoration, construction and
» Prime Minister: We will build new residential cities for all citizens, and their prices will not be
» The Minister of Finance is discussing, in an expanded meeting, reforming the tax system and maximizi
» An official statement defining the pillars of encouraging foreign investment in Iraq
» Advisor to the Prime Minister explains the importance of re-examining operating expenses and warns a
» Parliamentary position on the International Fund paper..Will Iraq's economy be exposed to "shocks"?
» The complexity of the budget negotiations confuses the leaders of the Kurdistan Democratic Party
» Expectations to pass the budget during the next two days
» Prime Minister: The new residential cities are for all citizens, not just for employees
» Parliamentarian: The Democrat agreed to the conditions of parliamentary finance regarding the budget
» Parliamentary Committee: Iraq can compensate for the losses of the voluntary reduction in oil produc
» An economic analysis of the IMF paper on Iraq.. What is the relationship between the salary bill?
» Parliamentarian: Disagreements over the delivery of Kurdistan's oil are still going on
» Former parliamentarian: International Monetary Fund reports on the Iraqi economy are unrealistic
» Al-Sudani: It is impossible for the middle and poor classes to buy a housing unit in residential com
» Iraq reveals a large number to prepare its employees and planning confirms: We are working to find o
» Sudanese financial advisor calls for strict scrutiny of operating expenses
» The Minister of Finance is discussing, in an expanded meeting, reforming the tax system and maximizi
» There is no room for development by relying on the World Bank
» The House of Representatives holds a session on Tuesday to vote on the budget
» Southern Refineries employees warn of a plot to sell the company to the private sector
» Two sources: OPEC + is working on a new agreement that includes baselines and cuts
» A legal expert explains the extent of the powers of the Finance Committee and its procedures regardi
» Iraqi Foreign Ministry: We discussed in all our international meetings the suffering of the Syrian p
» The framework accuses three Western embassies of supporting homosexuality in Iraq
» Independent deputy for / Nina /: The budget will be approved within days, despite the Democratic Par
» Today's newspapers are following the budget and the government's measures to deal with water scarcit
» Independent deputy for / Nina /: The budget will be approved within days, despite the Democratic Par
» Parliamentarian: The undisclosed share of the region reaches 18%
» The "greed" of oil companies deepens Iraq's water and environmental wounds
» In the currency auction.. The Central Bank sells more than 225 million dollars
» The Central Bank: Efforts to accelerate the use of electronic payment and its dissemination